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CD36 is a receptor for oxidized high density lipoprotein: Implications for the development of atherosclerosis
Author(s) -
Thorne Rick F.,
Mhaidat Nizar M.,
Ralston Kylie J.,
Burns Gordon F.
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.02.043
Subject(s) - cd36 , scavenger receptor , foam cell , atheroma , macrophage , lipoprotein , chemistry , cholesterol , receptor , low density lipoprotein , biochemistry , medicine , high density lipoprotein , endocrinology , microbiology and biotechnology , biology , in vitro
Atherosclerotic plaques result from the excessive deposition of cholesterol esters derived from lipoproteins and lipoprotein fragments. Tissue macrophage within the intimal space of major arterial vessels have been shown to play an important role in this process. We demonstrate in a transfection system using two human cell lines that the macrophage scavenger receptor CD36 selectively elicited lipid uptake from Cu 2+ ‐oxidized high density lipoprotein (HDL) but not from native HDL or low density lipoprotein (LDL). The uptake of oxHDL displayed morphological and biochemical similarities with the CD36‐dependent uptake of oxidized LDL. CD36‐mediated uptake of oxidized HDL by macrophage may therefore contribute to atheroma formation.