GTF2IRD1 regulates transcription by binding an evolutionarily conserved DNA motif ‘GUCE’ | Zendy

Thompson P.D. | Zendy; Webb M. | Zendy; Beckett W. | Zendy; Hinsley T. | Zendy; Jowitt T. | Zendy; Sharrocks A.D. | Zendy; Tassabehji M. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

GTF2IRD1 regulates transcription by binding an evolutionarily conserved DNA motif ‘GUCE’

Author(s) -

Thompson P.D.,

Webb M.,

Beckett W.,

Hinsley T.,

Jowitt T.,

Sharrocks A.D.,

Tassabehji M.

Publication year - 2007

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2007.02.040

Subject(s) - gene , transcription (linguistics) , biology , genetics , transcription factor , transcriptional regulation , motif (music) , microbiology and biotechnology , computational biology , philosophy , linguistics , physics , acoustics

GTF2IRD1 is a member of a family of transcription factors whose defining characteristic is varying numbers of a helix–loop–helix like motif, the I‐repeat. Here, we present functional analysis of human GTF2IRD1 in regulation of three genes ( HOXC8 , GOOSECOID and TROPONIN I SLOW ). We define a regulatory motif (GUCE–GTF2IRD1 Upstream Control Element) common to all three genes. GUCE is bound in vitro by domain I‐4 of GTF2IRD1 and mediates transcriptional regulation by GTF2IRD1 in vivo. Definition of this site will assist in identification of other downstream targets of GTF2IRD1 and elucidation of its role in the human developmental disorder Williams–Beuren syndrome.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research