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Effects of aging on triggering receptor expressed on myeloid cells (TREM)‐1‐induced PMN functions
Author(s) -
Fortin Carl F.,
Lesur Olivier,
Fulop Tamas
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.02.029
Subject(s) - receptor , degranulation , respiratory burst , chemotaxis , signal transduction , immunology , microbiology and biotechnology , phagocytosis , inflammation , granulocyte , biology , chemistry , biochemistry
Triggering receptor expressed on myeloid cell‐1 (TREM‐1) is a recently described receptor that has many effects on polymorphonuclear neutrophil (PMN), as the engagement of this receptor on PMN can induce phagocytosis, respiratory burst and degranulation. We studied the effects of aging on TREM‐1 engagement in human PMN. PMN from elderly were found to have impaired response following TREM‐1 engagement. Notably they were not able to modulate the TREM‐1‐induced respiratory burst as PMN from young did. TREM‐1 engagement could not reverse PMN survival following incubation with LPS or GM‐CSF in the elderly whereas it did in the young. The phosphorylation of TREM‐1 signal transduction molecules was altered with aging. Finally, TREM‐1 engagement could not drive the recruitment of TREM‐1 in the lipid‐rafts of the elderly explaining in part the altered response. The observed alterations in TREM‐1 response are possibly an important contributing factor in the higher incidence of sepsis‐related deaths in the elderly population.