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Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cells
Author(s) -
Perry Sara E.,
Robinson Philip,
Melcher Alan,
Quirke Philip,
Bühring Hans-Jörg,
Cook Graham P.,
Blair G. Eric
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.02.025
Subject(s) - downregulation and upregulation , gene , gene expression , microbiology and biotechnology , biology , cell culture , colorectal cancer , cell , cancer research , chemistry , cancer , genetics
Expression of CUB domain containing protein 1 (CDCP1) is upregulated in carcinoma cells. We quantitated CDCP1 gene expression in matched normal colon and tumour tissue and compared the level of expression to other genes upregulated in colorectal tumourigenesis. Furthermore, we show that the CDCP1 gene generates two transcripts which are co‐expressed in normal and matched tumour tissue as well as in the majority of cell lines analysed. However, intracellular localisation studies revealed that only one of these transcripts encodes a protein that is localised to the cell surface.