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Carbon inhibits vascular endothelial growth factor‐ and fibroblast growth factor‐promoted angiogenesis
Author(s) -
Murugesan Saravanababu,
Mousa Shaker A.,
O’Connor Laura J.,
Lincoln David W.,
Linhardt Robert J.
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.02.022
Subject(s) - angiogenesis , vascular endothelial growth factor , fibroblast growth factor , chorioallantoic membrane , basic fibroblast growth factor , growth factor , wound healing , microbiology and biotechnology , neovascularization , fibroblast , chemistry , cancer research , biology , immunology , biochemistry , vegf receptors , in vitro , receptor
Angiogenesis is important for normal growth and wound healing processes. An imbalance of the growth factors involved in this process, however, causes the acceleration of several diseases including malignant, ocular, and inflammatory diseases. Inhibiting angiogenesis through interfering with its pathway is a promising methodology to hinder the progression of these diseases. Herein, we studied the anti‐angiogenic effects of various carbon materials such as graphite, multiwalled carbon nanotubes and fullerenes in vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (FGF2)‐induced angiogenesis evaluated in the chick chorioallantoic membrane (CAM) model. All the carbon materials tested showed substantial anti‐angiogenic activity against either FGF2‐ or VEGF‐induced angiogenesis in the CAM model. Those carbon materials did not have any significant effects on basal angiogenesis in the absence of the added growth factors.