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Central administration of melanocortin agonist increased insulin sensitivity in diet‐induced obese rats
Author(s) -
Banno Ryoichi,
Arima Hiroshi,
Hayashi Masayuki,
Goto Motomitsu,
Watanabe Minemori,
Sato Ikuko,
Ozaki Nobuaki,
Nagasaki Hiroshi,
Ozaki Noriyuki,
Oiso Yutaka
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.02.019
Subject(s) - medicine , endocrinology , melanocortin , adipose tissue , insulin , melanocortin receptor , agonist , white adipose tissue , melanocortin 4 receptor , insulin resistance , insulin sensitivity , obesity , chemistry , receptor
In this study, we examined the effects of intracerebroventricular administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity in diet‐induced obese (DIO) rats. Although MTII treatment significantly decreased food intake and body weight for 10 days, there was no significant difference in body weight between MTII and pair‐fed groups. The insulin tolerance test showed that insulin sensitivity was significantly improved in the MTII group compared to the pair‐fed group. Furthermore, MTII treatment increased the number of small‐sized adipocytes in epididymal white adipose tissues, suggesting that MTII increased insulin sensitivity through action on the white adipose tissues in DIO rats.