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mGluR1 in the fundic glands of rat stomach
Author(s) -
San Gabriel Ana M.,
Maekawa Takami,
Uneyama Hisayuki,
Yoshie Sumio,
Torii Kunio
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.02.016
Subject(s) - gastric chief cell , stomach , immunohistochemistry , umami , blot , glutamate receptor , gastric mucosa , metabotropic glutamate receptor 1 , chemistry , medicine , biology , endocrinology , metabotropic glutamate receptor , taste , biochemistry , gene , receptor
l ‐glutamate not only confers cognitive discrimination for umami taste in the oral cavity, but also conveys sensory information to vagal afferent fibers in the gastric mucosa. We used RT‐PCR, western blotting, and immunohistochemistry to demonstrate that mGluR1 is located in glandular stomach. Double staining revealed that mGluR1 is found at the apical membrane of chief cells and possibly in parietal cells. Moreover, a diet with 1% l ‐glutamate induced changes in the expression of pepsinogen C mRNA in stomach mucosa. These data suggest that mGluR1 is involved in the gastric phase regulation of protein digestion.