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Iron overload in Hepc1 −/− mice is not impairing glucose homeostasis
Author(s) -
Ramey G.,
Faye A.,
Durel B.,
Viollet B.,
Vaulont S.
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.02.002
Subject(s) - medicine , endocrinology , glucose homeostasis , homeostasis , pancreas , insulin , diabetes mellitus , hepcidin , hereditary hemochromatosis , beta cell , islet , biology , hemochromatosis , chemistry , anemia , insulin resistance
Diabetes Mellitus is found with increasing frequency in iron overload patients with hemochromatosis. In these conditions, the pancreas shows predominant iron overload in acini but also islet β‐cells. We assess glucose homeostasis status in iron‐overloaded hepcidin‐deficient mice. These mice presented with heavy pancreatic iron deposits but only in the acini. The β‐cell function was found unaffected with a normal production and secretion of insulin. The mutant mice were not diabetic, responded as the control group to glucose and insulin challenges, with no alteration of insulin signalling in the muscle and the liver. These results indicate that, β‐cells iron deposits‐induced decreased insulin secretory capacity might be of primary importance to trigger diabetes in hemochromatosic patients.