Premium
Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae
Author(s) -
Suzuki Kuninori,
Ohsumi Yoshinori
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.01.096
Subject(s) - autophagy , autophagosome , saccharomyces cerevisiae , microbiology and biotechnology , yeast , biology , organelle , chemistry , biochemistry , apoptosis
Autophagy is a degradation process accompanied by dynamic membrane organization. In the yeast, Saccharomyces cerevisiae , about 30 ATG (autophagy‐related) genes have been identified as important genes for autophagy. Among them, 17 are indispensable for formation of the autophagosome, an organelle enclosed by a double lipid bilayer during starvation‐induced autophagy. Recently, a central structure for autophagosome generation, termed the pre‐autophagosomal structure, was identified. Despite intensive study, many questions regarding the mechanisms underlying autophagosome formation remain unanswered. In this review, we will give an overview of recent studies on the mechanisms of autophagosome formation and discuss these unresolved questions.