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Rab cascades and tethering factors in the endomembrane system
Author(s) -
Markgraf Daniel F.,
Peplowska Karolina,
Ungermann Christian
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.01.090
Subject(s) - endomembrane system , rab , tethering , gtpase , microbiology and biotechnology , effector , chemistry , biology , computational biology , endoplasmic reticulum , golgi apparatus
Rab GTPases are key proteins that determine organelle identity and operate at the center of fusion reactions. Like Ras, they act as switches that are connected to a diverse network of tethering factors, exchange factors and GTPase activating proteins. Recent studies suggest that Rabs are linked to each other via their effectors, thus coordinating protein transport in the endomembrane system. Within this review, we will focus on selected examples that highlight these issues.