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Redundant promoter elements mediate IL‐3‐induced expression of a novel cytokine‐inducible gene, cyclon
Author(s) -
Hoshino Akemi,
Fujii Hodaka
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.01.083
Subject(s) - socs6 , gene , biology , reporter gene , socs5 , cytokine , gene expression , coiled coil , microbiology and biotechnology , regulation of gene expression , socs3 , genetics , suppressor
Cytokines control cell differentiation, proliferation, and function by regulating gene expression program. Physiological roles and induction mechanisms of cytokine‐inducible genes are not fully understood. Here, we identified a novel immediate‐early cytokine‐responsive gene, cyclon (cytokine‐induced protein with coiled‐coil domain), which is induced in a hematopoietic cell line by interleukin 3 (IL‐3). cyclon gene encodes a phosphorylated nuclear protein consisting of repetitive sequences in the amino‐terminus and a coiled‐coil domain in the carboxyl‐terminus. A novel transient reporter assay revealed that mouse cyclon promoter contains redundant elements for IL‐3‐induced gene expression.