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Carnosine and its constituents inhibit glycation of low‐density lipoproteins that promotes foam cell formation in vitro
Author(s) -
Rashid Imran,
van Reyk David M.,
Davies Michael J.
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.01.082
Subject(s) - glycation , carnosine , chemistry , glycolaldehyde , foam cell , biochemistry , lipoprotein , low density lipoprotein , in vitro , lysine , amino acid , sterol o acyltransferase , cholesterol , receptor , catalysis
Glycation of low‐density lipoprotein (LDL) by reactive aldehydes, such as glycolaldehyde, can result in the cellular accumulation of cholesterol in macrophages. In this study, it is shown that carnosine, or its constituent amino acids β‐alanine and l ‐histidine, can inhibit the modification of LDL by glycolaldehyde when present at equimolar concentrations to the modifying agent. This protective effect was accompanied by inhibition of cholesterol and cholesteryl ester accumulation in human monocyte‐derived macrophages incubated with the glycated LDL. Thus, carnosine and its constituent amino acids may have therapeutic potential in preventing diabetes‐induced atherosclerosis.