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Anti‐angiogenic properties of myo ‐inositol trispyrophosphate in ovo and growth reduction of implanted glioma
Author(s) -
Sihn Gabin,
Walter Thomas,
Klein Jean-Claude,
Queguiner Isabelle,
Iwao Hiroshi,
Nicolau Claude,
Lehn Jean-Marie,
Corvol Pierre,
Gasc Jean-Marie
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.01.079
Subject(s) - angiogenesis , in ovo , chorioallantoic membrane , glioma , cancer research , chemistry , hypoxia (environmental) , regulator , inositol , microbiology and biotechnology , biology , biochemistry , embryo , receptor , organic chemistry , oxygen , gene
We investigate here the anti‐angiogenic properties of the synthetic compound myo ‐inositol trispyrophosphate (ITPP). By increasing oxy‐haemoglobin dissociation, ITPP has the potential to counteract the effects of hypoxia, a critical regulator of angiogenesis and cancer progression. ITPP inhibited angiogenesis of the chorioallantoic membrane (CAM), as analyzed with an original program dedicated to automated quantification of angiogenesis in this model. ITPP also markedly reduced tumor progression and angiogenesis in an experimental model of U87 glioma cell nodules grafted onto the CAM. These results point out the potential of ITPP for the development of a new class of anti‐angiogenic and anti‐cancer compounds.