Proteasome function is required for activation of programmed cell death in heat shocked tobacco Bright‐Yellow 2 cells | Zendy

Vacca Rosa A. | Zendy; Valenti Daniela | Zendy; Bobba Antonella | Zendy; de Pinto Maria C. | Zendy; Merafina Riccardo S. | Zendy; De Gara Laura | Zendy; Passarella Salvatore | Zendy; Marra Ersilia | Zendy

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Proteasome function is required for activation of programmed cell death in heat shocked tobacco Bright‐Yellow 2 cells

Author(s) -

Vacca Rosa A.,

Valenti Daniela,

Bobba Antonella,

de Pinto Maria C.,

Merafina Riccardo S.,

De Gara Laura,

Passarella Salvatore,

Marra Ersilia

Publication year - 2007

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2007.01.071

Subject(s) - mg132 , proteasome , programmed cell death , microbiology and biotechnology , caspase , proteases , cytochrome c , proteasome inhibitor , reactive oxygen species , apoptosis , protease , chemistry , heat shock , biochemistry , heat shock protein , biology , enzyme , gene

To find out whether and how proteasome is involved in plant programmed cell death (PCD) we measured proteasome function in tobacco cells undergoing PCD as a result of heat shock (HS‐PCD). Reactive oxygen species (ROS) production, cytochrome c levels and caspase‐3‐like protease activation were also measured in the absence or presence of MG132, a proteasome inhibitor. We show that proteasome activation occurs in early phase of HS‐PCD upstream of the caspase‐like proteases activation; moreover inhibition of proteasome function by MG132 results in prevention of PCD perhaps due to the prevention of ROS production, cytochrome c release and caspase‐3‐like protease activation.

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