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N − 3 PUFAs modulate global gene expression profile in cultured rat cardiomyocytes. Implications in cardiac hypertrophy and heart failure
Author(s) -
Bordoni Alessandra,
Astolfi Annalisa,
Morandi Luca,
Pession Andrea,
Danesi Francesca,
Di Nunzio Mattia,
Franzoni Monica,
Biagi PierLuigi,
Pession Annalisa
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.01.070
Subject(s) - downregulation and upregulation , gene expression , microbiology and biotechnology , gene , biology , inflammation , extracellular matrix , extracellular , muscle hypertrophy , myocyte , regulation of gene expression , endocrinology , genetics , immunology
In cardiac cells the effects of n − 3 PUFAs on the whole genome are still unknown despite their recognized cardioprotective effects and ability to modulate gene expression. We have evaluated the effects of n − 3 PUFAs supplementation on the global gene expression profile in cultured neonatal rat cardiomyocytes, detecting many genes related to lipid transport and metabolism among the upregulated ones. Many of the downregulated genes appeared related to inflammation, cell growth, extracellular and cardiac matrix remodelling, calcium movements and ROS generation. Our data allow to speculate that the cardioprotective effect of n − 3 PUFAs is related to a direct modulation of genes in cardiac cells.