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Transformation of the proteasome with age‐related macular degeneration
Author(s) -
Ethen Cheryl M.,
Hussong Stacy A.,
Reilly Cavan,
Feng Xiao,
Olsen Timothy W.,
Ferrington Deborah A.
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.01.061
Subject(s) - proteasome , macular degeneration , oxidative stress , inflammation , retina , retinal , retinal degeneration , degeneration (medical) , transformation (genetics) , immune system , microbiology and biotechnology , biology , chemistry , immunology , medicine , endocrinology , biochemistry , ophthalmology , neuroscience , gene
The proteasome mediates pathways associated with oxidative stress and inflammation, two pathogenic events correlated with age‐related macular degeneration (AMD). In human donor eyes corresponding to four stages of AMD, we found the proteasomal chymotrypsin‐like activity increased in neurosensory retina with disease progression. Increased activity correlated with a dramatic increase in the inducible subunits of the immunoproteasome, which was not due to an increase in CD45 positive immune cells in the retina. The novel observation of proteasome transformation may reflect retinal response to local inflammation or oxidative stress with AMD.