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Surfactin from Bacillus subtilis displays anti‐proliferative effect via apoptosis induction, cell cycle arrest and survival signaling suppression
Author(s) -
Kim Seo-young,
Kim Joo Young,
Kim Seol-Hee,
Bae Hyun Jin,
Yi Hwaseon,
Yoon Sang Hong,
Koo Bon Sung,
Kwon Moosik,
Cho Jae Youl,
Lee Choong-Eun,
Hong Sungyoul
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.01.059
Subject(s) - surfactin , cell cycle , microbiology and biotechnology , apoptosis , cyclin dependent kinase 2 , cell growth , dna fragmentation , protein kinase b , annexin , poly adp ribose polymerase , kinase , cyclin dependent kinase , cyclin dependent kinase 4 , cyclin b1 , biology , cell cycle checkpoint , chemistry , signal transduction , bacillus subtilis , cyclin dependent kinase 1 , programmed cell death , protein kinase a , biochemistry , polymerase , dna , genetics , bacteria
The effect of surfactin on the proliferation of LoVo cells, a human colon carcinoma cell line, was examined. Surfactin strongly blocked the proliferation of LoVo cells by inducing pro‐apoptotic activity and arresting the cell cycle, according to several lines of evidence on DNA fragmentation, Annexin V staining, and altered levels of poly (ADP‐ribose) polymerase, caspase‐3, p21 WAF1/Cip1 , p53, CDK2 and cyclin E. The anti‐proliferative activity of surfactin was mediated by inhibiting extracellular‐related protein kinase and phosphoinositide 3‐kinase/Akt activation, as assessed by phosphorylation levels. Therefore, our data suggest that surfactin may have anti‐cancer properties as a result of its ability to downregulate the cell cycle and suppress its survival.