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β‐Catenin regulates P‐cadherin expression in mammary basal epithelial cells
Author(s) -
Faraldo Marisa M.,
Teulière Jérôme,
Deugnier Marie-Ange,
Birchmeier Walter,
Huelsken Joerg,
Thiery Jean Paul,
Cano Amparo,
Glukhova Marina A.
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.01.053
Subject(s) - catenin , cadherin , basal (medicine) , microbiology and biotechnology , expression (computer science) , biology , chemistry , endocrinology , signal transduction , wnt signaling pathway , genetics , cell , computer science , programming language , insulin
P‐cadherin expression is restricted to the basal layer of stratified epithelia including that of the mammary gland. Although evidence for an important role of P‐cadherin in mammary morphogenesis and tumorigenesis is increasing, the mechanisms that regulate its expression are poorly understood. We show that in basal mammary epithelial cells, β‐catenin is associated with the P‐cadherin promoter and activates its expression independently of LEF/TCF in a cell‐type specific manner. Down‐regulation of endogenous β‐catenin levels by RNA interference technique inhibited P‐cadherin promoter activity. In vivo, in skin and mammary gland of mutant mice, activation of β‐catenin signalling correlates with up‐regulation of P‐cadherin expression. These data suggest that β‐catenin‐dependent modulation of P‐cadherin expression can contribute to the establishment of the basal phenotype.