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Bioinformatic tools uncover the C‐terminal strand of Rubisco's large subunit as hot‐spot for specificity‐enhancing mutations
Author(s) -
Burisch C.,
Wildner G.F.,
Schlitter J.
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.01.043
Subject(s) - rubisco , specificity factor , protein subunit , carboxylation , hot spot (computer programming) , computational biology , biology , genetics , chemistry , biochemistry , gene , rna , computer science , rna dependent rna polymerase , operating system , catalysis
Here, we (a) present an analysis of sequences of the large subunit which reliably finds specificity‐enhancing mutations and ranks them according to the probability of success. For mutations near the C‐terminus, we (b) show by simulations that the positive influence they have on specificity can be explained by the time‐window hypothesis.