Premium
Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle
Author(s) -
Bailey Leslie,
Gylfe Åsa,
Sundin Charlotta,
Muschiol Sandra,
Elofsson Mikael,
Nordström Peter,
Henriques-Normark Birgitta,
Lugert Raimond,
Waldenström Anders,
Wolf-Watz Hans,
Bergström Sven
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.01.013
Subject(s) - secretion , chlamydia , type three secretion system , intracellular , biology , microbiology and biotechnology , pathogenesis , small molecule , chemistry , immunology , biochemistry , gene , mutant
Intracellular parasitism by Chlamydiales is a complex process involving transmission of metabolically inactive particles that differentiate, replicate, and re‐differentiate within the host cell. A type three secretion system (T3SS) has been implicated in this process. We have here identified small molecules of a chemical class of acylated hydrazones of salicylaldehydes that specifically blocks the T3SS of Chlamydia . These compounds also affect the developmental cycle showing that the T3SS has a pivotal role in the pathogenesis of Chlamydia . Our results suggest a previously unexplored avenue for development of novel anti‐chlamydial drugs.