Small molecule inhibitors of type III secretion in  Yersinia  block the  Chlamydia pneumoniae  infection cycle | Zendy

Bailey Leslie | Zendy; Gylfe Åsa | Zendy; Sundin Charlotta | Zendy; Muschiol Sandra | Zendy; Elofsson Mikael | Zendy; Nordström Peter | Zendy; Henriques-Normark Birgitta | Zendy; Lugert Raimond | Zendy; Waldenström Anders | Zendy; Wolf-Watz Hans | Zendy; Bergström Sven | Zendy

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Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle

Author(s) -

Bailey Leslie,

Gylfe Åsa,

Sundin Charlotta,

Muschiol Sandra,

Elofsson Mikael,

Nordström Peter,

Henriques-Normark Birgitta,

Lugert Raimond,

Waldenström Anders,

Wolf-Watz Hans,

Bergström Sven

Publication year - 2007

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2007.01.013

Subject(s) - secretion , chlamydia , type three secretion system , intracellular , biology , microbiology and biotechnology , pathogenesis , small molecule , chemistry , immunology , biochemistry , gene , mutant

Intracellular parasitism by Chlamydiales is a complex process involving transmission of metabolically inactive particles that differentiate, replicate, and re‐differentiate within the host cell. A type three secretion system (T3SS) has been implicated in this process. We have here identified small molecules of a chemical class of acylated hydrazones of salicylaldehydes that specifically blocks the T3SS of Chlamydia . These compounds also affect the developmental cycle showing that the T3SS has a pivotal role in the pathogenesis of Chlamydia . Our results suggest a previously unexplored avenue for development of novel anti‐chlamydial drugs.

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