UCP2 is a mitochondrial transporter with an unusual very short half‐life | Zendy

Rousset Sophie | Zendy; Mozo Julien | Zendy; Dujardin Geneviève | Zendy; Emre Yalin | Zendy; Masscheleyn Sandrine | Zendy; Ricquier Daniel | Zendy; Cassard-Doulcier Anne-Marie | Zendy

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UCP2 is a mitochondrial transporter with an unusual very short half‐life

Author(s) -

Rousset Sophie,

Mozo Julien,

Dujardin Geneviève,

Emre Yalin,

Masscheleyn Sandrine,

Ricquier Daniel,

Cassard-Doulcier Anne-Marie

Publication year - 2007

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2007.01.010

Subject(s) - mitochondrion , thermogenin , uncoupling protein , transporter , inner mitochondrial membrane , mitochondrial carrier , microbiology and biotechnology , mitochondrial dna , membrane potential , biology , biophysics , chemistry , thermogenesis , biochemistry , gene , brown adipose tissue , bacterial outer membrane , adipose tissue , escherichia coli

This study focused on the stability of UCP2 (uncoupling protein 2), a mitochondrial carrier located in the inner membrane of mitochondrion. UCP2 is very unstable, with a half‐life close to 30 min, compared to 30 h for its homologue UCP1, a difference that may highlight different physiological functions. Heat production by UCP1 in brown adipocytes is generally a long and adaptive phenomenon, whereas control of mitochondrial ROS by UCP2 needs more subtle regulation. We show that a mutation in UCP2 shown to modify its activity, actually decreases its stability.

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