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UCP2 is a mitochondrial transporter with an unusual very short half‐life
Author(s) -
Rousset Sophie,
Mozo Julien,
Dujardin Geneviève,
Emre Yalin,
Masscheleyn Sandrine,
Ricquier Daniel,
Cassard-Doulcier Anne-Marie
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.01.010
Subject(s) - transporter , chemistry , mitochondrion , biochemistry , gene
This study focused on the stability of UCP2 (uncoupling protein 2), a mitochondrial carrier located in the inner membrane of mitochondrion. UCP2 is very unstable, with a half‐life close to 30 min, compared to 30 h for its homologue UCP1, a difference that may highlight different physiological functions. Heat production by UCP1 in brown adipocytes is generally a long and adaptive phenomenon, whereas control of mitochondrial ROS by UCP2 needs more subtle regulation. We show that a mutation in UCP2 shown to modify its activity, actually decreases its stability.