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The effect of pleiotrophin signaling on adipogenesis
Author(s) -
Gu Dayong,
Yu Bing,
Zhao Chen,
Ye Wenbin,
Lv Qing,
Hua Zhong,
Ma Jiangan,
Zhang Yaou
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.12.043
Subject(s) - adipogenesis , pleiotrophin , wnt signaling pathway , gsk 3 , microbiology and biotechnology , signal transduction , chemistry , protein kinase b , pi3k/akt/mtor pathway , glycogen synthase , phosphorylation , biology , biochemistry , growth factor , receptor , mesenchymal stem cell
Pleiotrophin (PTN) plays diverse roles in cell growth and differentiation. In this investigation, we demonstrate that PTN plays a negative role in adipogensis and that glycogen synthase kinase 3β (GSK‐3β) and β‐catenin are involved in the regulation of PTN‐mediated preadipocyte differentiation. Knocking down the expression of PTN using siRNA resulted in an increase in phospho‐GSK‐3β expression, and the accumulation of nuclear β‐catenin, which are critical downstream signaling proteins for both the PTN and Wnt signaling pathways. Our investigation suggests that there is a PTN/PI3K/AKT/GSK‐3β/β‐catenin signaling pathway, which cross‐talks with the Wnt/Fz/GSK‐3β/β‐catenin pathway and negatively regulates adipogenesis.