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Sequestosome 1/p62 – More than just a scaffold
Author(s) -
Seibenhener M. Lamar,
Geetha Thangiah,
Wooten Marie W.
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.12.027
Subject(s) - sequestosome 1 , ubiquitin , internalization , microbiology and biotechnology , receptor , scaffold protein , chemistry , computational biology , biology , signal transduction , biochemistry , autophagy , apoptosis , gene
The interaction of proteins with ubiquitin receptors is key to solving the mystery that surrounds the functional role ubiquitin chains play in directing traffic. The specificity of these interactions is largely mediated by UbL/UBA domains. Sequestosome 1/p62 is a protein that is gaining attention as it is intimately involved in cell signaling, receptor internalization, and protein turnover. Herein we review recent advances in the field.