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Sinusoidal swinging dynamics of the telomere repair and cell growth activation functions of telomerase in rat liver cancer cells
Author(s) -
Wolfrom Claire,
Martin Olivier C.,
Laurent Michel,
Deschatrette Jean
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.12.007
Subject(s) - telomere , telomerase , microbiology and biotechnology , telomerase reverse transcriptase , biology , cell growth , cancer cell , function (biology) , rna , dna , cancer , gene , genetics
Telomerase is a multimolecular complex of reverse transcriptase, RNA template, and regulatory proteins. It has two known functions: catalysis of the addition of [TTAGGG] repeats to telomeric DNA and the activation of various genes controlling cell proliferation. The possible coordination of these two functions is a key issue in understanding the growth of cancer cells. We report long‐term changes to this complex system, as shown by specific data analysis methods. We show that the dynamics of the two functions of telomerase are tightly linked, with a change in predominant function every 13–14 weeks. The conservative behavior of this dynamic system probably accounts for the persistent proliferation of cancer cells.