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Characterisation of lipofuscin‐like lysosomal inclusion bodies from human placenta
Author(s) -
Schröder Bernd,
Elsässer Hans-Peter,
Schmidt Bernhard,
Hasilik Andrej
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.12.005
Subject(s) - lipofuscin , lysosome , lysis , membrane , microbiology and biotechnology , chemistry , human placenta , placenta , biology , biochemistry , pregnancy , enzyme , fetus , genetics
Here we show that human term placenta contains lipofuscin‐like lysosomal inclusions, a phenomenon usually associated with senescence in postmitotic cells. These findings imply that a simple pelleting of a lysosomal lysate is not appropriate for the isolation of lysosomal membranes, as the inclusions tend to be sedimented with the membranes.