Premium
MARCH‐IX mediates ubiquitination and downregulation of ICAM‐1
Author(s) -
Hoer Simon,
Smith Lorraine,
Lehner Paul J.
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.11.075
Subject(s) - ubiquitin ligase , downregulation and upregulation , ubiquitin , microbiology and biotechnology , ubiquitin protein ligases , regulator , chemistry , biology , gene , genetics
The membrane associated RING‐CH (MARCH) family of genes encode a novel group of RING‐type ubiquitin E3 ligases. Overexpression of one of these family members, MARCH‐IX, leads to a downregulation of cell surface major histocompatibility complex (MHC) class I and CD4. Here, we identify MARCH‐IX as the first ubiquitin E3 ligase to control expression of the critical cell adhesion molecule ICAM‐1. MARCH‐IX expression causes ubiquitination and downregulation of ICAM‐1 and a short alternative transcript of MARCH‐IX lacking the RING‐CH domain, termed MARCH‐IX RINGless, is shown to act as a positive regulator of MARCH‐IX activity.