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Alternative splicing of human and mouse NPFF2 receptor genes: Implications to receptor expression
Author(s) -
Änkö Minna-Liisa,
Östergård Maria,
Lintunen Minnamaija,
Panula Pertti
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.11.063
Subject(s) - 5 ht5a receptor , alternative splicing , gene , receptor , microbiology and biotechnology , biology , genetics , exon
Alternative splicing has an important role in the tissue‐specific regulation of gene expression. Here we report that similar to the human NPFF2 receptor, the mouse NPFF2 receptor is alternatively spliced. In human the presence of three alternatively spliced receptor variants were verified, whereas two NPFF2 receptor variants were identified in mouse. The alternative splicing affected the 5′ untranslated region of the mouse receptor and the variants in mouse were differently distributed. The mouse NPFF system may also have species‐specific features since the NPFF2 receptor mRNA expression differs from that reported for rat.