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Mice deficient in Dmrt7 show infertility with spermatogenic arrest at pachytene stage
Author(s) -
Kawamata Masaki,
Nishimori Katsuhiko
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.10.066
Subject(s) - spermatogenesis , epididymis , andrology , knockout mouse , biology , male infertility , sperm , gene knockout , gene , infertility , medicine , endocrinology , genetics , pregnancy
Genes including DM domain regulate sexual development in diverse metazoan phyla. One of these genes, Dmrt7 , was expressed only in testes of adult mice. To determine the role of Dmrt7 in mice, we generated Dmrt7 ‐knockout mice ( Dmrt7 −/− ). Although the Dmrt7 −/− showed normal growth, null males were infertile. No sperm was detected in the epididymis of Dmrt7 −/− adult males. Absence of spermatids in a histological analysis, decreased expression of Ccna1 mRNA and the accumulation of SCP3‐positive spermatocytes showed the arrest of spermatogenesis at the pachytene stage in the Dmrt7 ‐knockout mice.