Premium
IL‐1 receptor antagonist in metabolic diseases: Dr Jekyll or Mr Hyde?
Author(s) -
Perrier Stephane,
Darakhshan Froogh,
Hajduch Eric
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.10.061
Subject(s) - interleukin 1 receptor antagonist , receptor antagonist , antagonist , insulin resistance , diabetes mellitus , obesity , receptor , medicine , bioinformatics , biology , endocrinology
This minireview gets an insight into recent findings on the implication of IL‐1ra and its gene polymorphism in diabetes and obesity, discusses the potential dual effects of IL‐1ra observed in different models, and comments on future directions.