A novel subunit of axonemal dynein conserved among lower and higher eukaryotes | Zendy

Yamamoto Ryosuke | Zendy; Yanagisawa Haru-aki | Zendy; Yagi Toshiki | Zendy; Kamiya Ritsu | Zendy

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A novel subunit of axonemal dynein conserved among lower and higher eukaryotes

Author(s) -

Yamamoto Ryosuke,

Yanagisawa Haru-aki,

Yagi Toshiki,

Kamiya Ritsu

Publication year - 2006

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2006.10.047

Subject(s) - dynein , flagellum , cilium , intraflagellar transport , biology , protein subunit , chlamydomonas , dynactin , microbiology and biotechnology , microtubule , immunoprecipitation , axoneme , immunoglobulin light chain , mutant , genetics , gene , antibody

To elucidate the subunit composition of axonemal inner‐arm dynein, we examined a 38 kDa protein (p38) co‐purified with a Chlamydomonas inner arm subspecies, dynein d. We found it is a novel protein conserved among a variety of organisms with motile cilia and flagella. Immunoprecipitation using specific antibody verified its association with a heavy chain, actin and a previously identified light chain (p28). Unexpectedly, mutant axonemes lacking dynein d and other dyneins retained reduced amounts of p38. This finding suggests that p38 is involved in the docking of dynein d to specific loci.

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