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Circulating gastrin is increased in hemochromatosis
Author(s) -
Smith Kelly A.,
Kovac Suzana,
Anderson Gregory J.,
Shulkes Arthur,
Baldwin Graham S.
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.10.021
Subject(s) - gastrin , hemochromatosis , hereditary hemochromatosis , medicine , endocrinology , gastric acid , secretion , chemistry , hormone , peptide hormone , gastrointestinal hormone , ferric , organic chemistry
Gastric acid production is important in intestinal iron absorption. The peptide hormone gastrin exists in both amidated and non‐amidated forms, which stimulate and potentiate gastric acid secretion, respectively. Since non‐amidated gastrins require ferric ions for biological activity in vitro, this study investigated the connection between iron status and gastrin by measurement of circulating gastrin concentrations in mice and humans with hemochromatosis. Gastrin concentrations are increased in the plasma and gastric mucosa of Hfe −/− mice, and in the sera of humans with HFE‐related hemochromatosis. The discovery of a relationship between iron status and circulating gastrin concentrations opens a new perspective on the mechanisms of iron homeostasis.