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Homer proteins control neuronal differentiation through IP 3 receptor signaling
Author(s) -
Tanaka Masahiko,
Duncan R. Scott,
McClung Nathalie,
Yannazzo Jo-Ann S.,
Hwang Sung-Yong,
Marunouchi Tohru,
Inokuchi Kaoru,
Koulen Peter
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.10.013
Subject(s) - synaptogenesis , biology , microbiology and biotechnology , dendritic spine , neuroscience , hippocampal formation
Neurons expand, sustain or prune their dendritic trees during ontogenesis [Cline, H.T. (2001). Dendritic arbor development and synaptogenesis. Curr. Opin. Neurobiol. 11, 118–126; Wong, W.T. and Wong, R.O.L. (2000) Rapid dendritic movements during synapse formation and rearrangement. Curr. Opin. Neurobiol. 10, 118–124] which critically depends on neuronal activity [Wong, W.T., Faulkner‐Jones, B.E., Sanes, J.R. and Wong, R.O.L. (2000) Rapid dendritic remodeling in the developing retina: dependence on neurotransmission and reciprocal regulation by Rac and Rho. J. Neurosci. 20, 5024–5036; Li, Z., Van Aelst, L. and Cline, H.T. (2000) Rho GTPases regulate distinct aspects of dendritic arbor growth in Xenopus central neurons in vivo. Nat. Neurosci. 3, 217–225; Wong, W.T. and Wong, R.O.L. (2001) Changing specificity of neurotransmitter regulation of rapid dendritic remodeling during synaptogenesis. Nat. Neurosci. 4, 351–352.] and sub‐cellular Ca 2+ signals [Lohmann, C., Myhr, K.L. and Wong, R.O. (2002) Transmitter‐evoked local calcium release stabilizes developing dendrites, Nature 418, 177–181.]. The role of synaptic clustering proteins connecting both processes is unclear. Here, we show that expression levels of Vesl‐1/Homer 1 isoforms critically control properties of Ca 2+ release from intracellular stores and dendritic morphology of CNS neurons. Vesl‐1L/Homer 1c, an isoform with a functional WH1 and coiled‐coil domain, but not isoforms missing these features were capable of potentiating intracellular calcium signaling activity indicating that such regulatory interactions function as a general paradigm in cellular differentiation and are subject to changes in expression levels of Vesl/Homer isoforms.