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The Bysl gene product, bystin, is essential for survival of mouse embryos
Author(s) -
Aoki Rui,
Suzuki Nao,
Paria Bibhash C.,
Sugihara Kazuhiro,
Akama Tomoya O.,
Raab Gerhard,
Miyoshi Masaya,
Nadano Daita,
Fukuda Michiko N.
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.09.072
Subject(s) - blastocyst , embryo , epiblast , andrology , biology , embryonic stem cell , microbiology and biotechnology , embryogenesis , gene , gastrulation , genetics , medicine
Human bystin is a cytoplasmic protein directly binding to trophinin, a cell adhesion molecule potentially involved in human embryo implantation. The present study shows that bystin is expressed in luminal and glandular epithelia in the mouse uterus at peri‐implantation stages. In fertilized embryos, bystin was not seen until blastocyst stage. Bystin expression started during hatching and increased in expanded blastocyst. However, bystin apparently disappeared from the blastocyst during implantation. After implantation bystin re‐appeared in the epiblast. Targeted disruption of the mouse bystin gene, Bysl , resulted in embryonic lethality shortly after implantation, indicating that bystin is essential for survival of mouse embryos.