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UCP3 in muscle wasting, a role in modulating lipotoxicity?
Author(s) -
Minnaard Ronnie,
Schrauwen Patrick,
Schaart Gert,
Hesselink Matthijs K.C.
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.08.066
Subject(s) - lipotoxicity , ucp3 , medicine , endocrinology , oxidative stress , wasting , chemistry , biology , uncoupling protein , adipose tissue , insulin resistance , insulin , brown adipose tissue
UCP3 has been postulated to function in the defense against lipid‐induced oxidative muscle damage (lipotoxicity). We explored this hypothesis during cachexia in rats (zymosan‐induced sepsis), a condition characterized by increased oxidative stress and supply of fatty acids to the muscle. Muscle UCP3 protein content was increased 2, 6 and 11 days after zymosan injection. Plasma FFA levels were increased at day 2, but dropped below control levels on days 6 and 11. Muscular levels of the lipid peroxidation byproduct 4‐hydroxy‐2‐nonenal (4‐HNE) were increased at days 6 and 11 in zymosan‐treated rats, supporting a role for UCP3 in modulating lipotoxicity during cachexia.