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Drug‐induced phospholipidosis
Author(s) -
Anderson Nora,
Borlak Jürgen
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.08.061
Subject(s) - phospholipidosis , drug , lysosome , lamellar granule , phospholipid , intracellular , drug metabolism , pharmacology , metabolism , chemistry , biology , biochemistry , membrane , enzyme , pulmonary surfactant
Drug‐induced phospholipidosis is characterized by intracellular accumulation of phospholipids with lamellar bodies, most likely from an impaired phospholipid metabolism of the lysosome. Organs affected by phospholipidosis exhibit inflammatory reactions and histopathological changes. Despite significant advances in the understanding of drug‐altered lipid metabolism, the relationship between impaired phospholipid metabolism and drug‐induced toxicity remains enigmatic. Here we review molecular features of inheritable lysosomal storage disorders as a molecular mimicry of drug‐induced phospholipidosis for an improved understanding of adverse drug reaction.