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Moderate overexpression of AIB1 triggers pre‐neoplastic changes in mammary epithelium
Author(s) -
Avivar Álvaro,
García-Macias María Carmen,
Ascaso Emma,
Herrera Guadalupe,
O'Connor José-Enrique,
de Mora Jaime Font
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.08.057
Subject(s) - cyclin d1 , epithelium , cancer research , breast cancer , hyperplasia , mammary gland , nuclear receptor coactivator 3 , cell cycle , biology , coactivator , genetically modified mouse , cell growth , cyclin , endocrinology , cyclin d , medicine , cancer , transgene , estrogen receptor , pathology , transcription factor , gene , biochemistry , genetics
Here we report a new model of pre‐clinical breast cancer which has been generated by overexpressing the steroid receptor coactivator AIB1 at moderate levels in breast epithelium. Transgenic female mice display mammary hyperplasia at the onset of puberty, consistent with enhanced proliferation of primary mammary epithelial cultures and augmented levels of cyclin D1 and E‐cadherin. Studies of BrdU incorporation revealed that AIB1 localizes to the nucleus during or after S phase, implicating a new role for AIB1 in cell‐cycle progression subsequent to G1. Our findings suggest that moderate overexpression of AIB1 may represent one of the pre‐neoplastic changes in breast tissue.

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