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C‐reactive protein inhibits in vitro oxidation of low‐density lipoprotein
Author(s) -
Rufail Miguel L.,
Ramage Samuel C.,
van Antwerpen Rik
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.08.045
Subject(s) - chemistry , low density lipoprotein , lipoprotein , in vivo , in vitro , antioxidant , c reactive protein , phospholipid , phosphatidylcholine , biochemistry , albumin , lipid oxidation , liposome , reactive oxygen species , medicine , endocrinology , cholesterol , inflammation , biology , membrane , microbiology and biotechnology
C‐reactive protein (CRP) is elevated in cardiovascular disease and binds to oxidized phosphatidylcholine (oxPtC) in the low‐density lipoprotein (LDL) surface. In the present study, we tested if CRP influences the susceptibility of LDL to oxidation. At physiological concentrations of 1–7 μg/ml, CRP strongly inhibited copper‐mediated oxidation of LDL and phospholipid liposomes in a concentration‐dependent manner. Similar concentrations of different monoclonal antibodies or albumin did not influence LDL oxidation. Antioxidant activity of CRP was inhibited by phosphocholine (PC), indicating that the observed activity involves binding of CRP to oxPtC. These results suggest that CRP may limit atherogenic oxidation of LDL in vivo.