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How T lymphocytes recognize lipid antigens
Author(s) -
De Libero Gennaro,
Mori Lucia
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.08.029
Subject(s) - antigen , immune system , antigen presentation , immunology , antigen processing , biology , internalization , cd1 , t lymphocyte , microbiology and biotechnology , chemistry , antigen presenting cell , t cell , biochemistry , cell
Recognition of lipid antigens by T lymphocytes is well established. Lipids are recognized by T cells when presented in association with CD1 antigen‐presenting molecules. Both microbial and self lipids stimulate specific T lymphocytes, thus participating in immune reactions during infections and autoimmune diseases. The immune system uses a variety of strategies to solubilise lipid antigens, to facilitate their internalization, processing, and loading on CD1 molecules. Recent studies in the field of lipid antigen presentation have revealed new mechanisms which allow the immune system to sense lipids as stimulatory antigens.
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