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Identification of human low‐density lipoprotein receptor as a novel target gene regulated by liver X receptor alpha
Author(s) -
Ishimoto Kenji,
Tachibana Keisuke,
Sumitomo Mikako,
Omote Shiho,
Hanano Ikuko,
Yamasaki Daisuke,
Watanabe Yuichiro,
Tanaka Toshiya,
Hamakubo Takao,
Sakai Juro,
Kodama Tatsuhiko,
Doi Takefumi
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.08.010
Subject(s) - liver x receptor , liver x receptor alpha , retinoid x receptor , nuclear receptor , ldl receptor , hepatoblastoma , liver receptor homolog 1 , biology , retinoid x receptor alpha , receptor , chemistry , endocrinology , cholesterol , lipoprotein , medicine , biochemistry , transcription factor , gene
Liver X receptor alpha (LXRα) is a member of the nuclear receptor superfamily that is activated by oxysterols, and plays a pivotal role in regulating the metabolism, transport and uptake of cholesterol. Here, we demonstrate that LXRα also regulates the low‐density lipoprotein receptor ( LDLR ) gene, which mediates the endocytic uptake of LDL cholesterol in the liver. An LXR agonist induced the expression of LDLR in cultured hepatoblastoma cells. Moreover, the LDLR promoter contained an LXR response element that was recognized by LXRα/RXRα (retinoid X receptor alpha) heterodimers in hepatoblastoma cells. These results suggest a novel pathway whereby LXRα might modulate cholesterol metabolism.