Retracted: Selective modulation of the CAP/Cbl pathway in the adipose tissue of high fat diet treated rats | Zendy

Prada Patrícia Oliveira | Zendy; Pauli José Rodrigo | Zendy; Ropelle Eduardo Rochete | Zendy; Zecchin Henrique Gottardello | Zendy; Carvalheira José Barreto Campello | Zendy; Velloso Lício Augusto | Zendy; Saad Mario José Abdalla | Zendy

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Retracted: Selective modulation of the CAP/Cbl pathway in the adipose tissue of high fat diet treated rats

Author(s) -

Prada Patrícia Oliveira,

Pauli José Rodrigo,

Ropelle Eduardo Rochete,

Zecchin Henrique Gottardello,

Carvalheira José Barreto Campello,

Velloso Lício Augusto,

Saad Mario José Abdalla

Publication year - 2006

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2006.08.004

Subject(s) - adipose tissue , chemistry , endocrinology , medicine , modulation (music) , biochemistry , philosophy , aesthetics

A high‐fat diet (HFD) is associated with reduced glucose uptake in muscle, but not in adipose tissue. In the present study, we investigated whether a HFD can modulate glucose uptake in adipose tissue by increasing signal transduction through the CAP/Cbl pathway, independently of the PI3‐K/Akt pathway. Our results suggest that, in HFD, the differential regulation of insulin‐induced glucose uptake between skeletal muscle and adipose tissue may, in part, be a consequence of the CAP/Cbl/C3G pathway, since the expression of CAP and Cbl, and also the activation of this pathway were increased in adipose tissue but not in muscle.

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