Extracellular tau is toxic to neuronal cells | Zendy

Gómez-Ramos Alberto | Zendy; Díaz-Hernández Miguel | Zendy; Cuadros Raquel | Zendy; Hernández Félix | Zendy; Avila Jesús | Zendy

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Extracellular tau is toxic to neuronal cells

Author(s) -

Gómez-Ramos Alberto,

Díaz-Hernández Miguel,

Cuadros Raquel,

Hernández Félix,

Avila Jesús

Publication year - 2006

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2006.07.078

Subject(s) - extracellular , intracellular , microbiology and biotechnology , calcium in biology , chemistry , muscarinic acetylcholine receptor , calcium , tau protein , toxicity , neurodegeneration , programmed cell death , receptor , biophysics , biochemistry , biology , alzheimer's disease , medicine , disease , apoptosis , organic chemistry

The degeneration of neurons in disorders such as Alzheimer's disease has an immediate consequence, the release of intracellular proteins into the extracellular space. One of these proteins, tau, has proven to be toxic when added to cultured neuronal cells. This toxicity varies according to the degree of protein aggregation. The addition of tau to cultured neuroblastoma cells provoked an increase in the levels of intracellular calcium, which is followed by cell death. We suggest that this phenomenon may be mediated by the interaction of tau with muscarinic receptors, which promotes the liberation of calcium from intracellular stores.

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