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Identification of mobile cholesterol compounds in experimental gliomas by 1 H MRS in vivo: Effects of ganciclovir‐induced apoptosis on lipids
Author(s) -
Liimatainen Timo,
Lehtimäki Kimmo,
Ala-Korpela Mika,
Hakumäki Juhana
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.07.062
Subject(s) - in vivo , cholesterol , lipid metabolism , apoptosis , chemistry , glioma , biochemistry , biology , cancer research , genetics
This letter presents a novel identification and analysis of mobile cholesterol compounds in an experimental glioma model by 1 H MRS in vivo. The cholesterol compounds turned out to comprise as much as 17 mol% of MRS visible total lipids. The results also imply partly associated accumulation of 1 H MRS detectable cholesterol compounds and unsaturated lipids during gene therapy‐induced apoptosis, and indicate that the contribution of cholesterol compounds cannot be bypassed in spectral lipid analysis. The introduced 1 H MRS approach facilitates a non‐invasive follow‐up of mobile cholesterol compounds, paving way for studies of tumour cholesterol metabolism in vivo.