Differential induction of electrophile‐responsive element‐regulated genes by  n − 3 and  n − 6 polyunsaturated fatty acids | Zendy

van Beelen Vincent A. | Zendy; Aarts Jac M.M.J.G. | Zendy; Reus Astrid | Zendy; Mooibroek Hans | Zendy; Sijtsma Lolke | Zendy; Bosch Dirk | Zendy; Rietjens Ivonne M.C.M. | Zendy; Alink Gerrit M. | Zendy

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Differential induction of electrophile‐responsive element‐regulated genes by n − 3 and n − 6 polyunsaturated fatty acids

Author(s) -

van Beelen Vincent A.,

Aarts Jac M.M.J.G.,

Reus Astrid,

Mooibroek Hans,

Sijtsma Lolke,

Bosch Dirk,

Rietjens Ivonne M.C.M.,

Alink Gerrit M.

Publication year - 2006

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2006.07.028

Subject(s) - polyunsaturated fatty acid , docosahexaenoic acid , eicosapentaenoic acid , arachidonic acid , biochemistry , chemistry , enzyme , biology , fatty acid

In this study the n − 3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid and docosahexaenoic acid appear to be effective inducers of electrophile‐responsive element (EpRE) regulated genes, whereas the n − 6 PUFA arachidonic acid is not. These n − 3 PUFAs need to be oxidized to induce EpRE‐regulated gene expression, as the antioxidant vitamin E can partially inhibit the PUFA induced dose‐dependent effect. Results were obtained using a reporter gene assay, real‐time RT‐PCR and enzyme activity assays. The induction of EpRE‐regulated phase II genes by n − 3 PUFAs may be a major pathway by which n − 3 PUFAs, in contrast to n − 6 PUFAs, are chemopreventive and anticarcinogenic.

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