NF1  mRNA biogenesis: Effect of the genomic milieu in splicing regulation of the  NF1  exon 37 region | Zendy

Baralle Marco | Zendy; Skoko Natasa | Zendy; Knezevich Anna | Zendy; De Conti Laura | Zendy; Motti Dario | Zendy; Bhuvanagiri Madhuri | Zendy; Baralle Diana | Zendy; Buratti Emanuele | Zendy; Baralle Francisco E. | Zendy

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NF1 mRNA biogenesis: Effect of the genomic milieu in splicing regulation of the NF1 exon 37 region

Author(s) -

Baralle Marco,

Skoko Natasa,

Knezevich Anna,

De Conti Laura,

Motti Dario,

Bhuvanagiri Madhuri,

Baralle Diana,

Buratti Emanuele,

Baralle Francisco E.

Publication year - 2006

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2006.07.018

Subject(s) - exon , rna splicing , biogenesis , messenger rna , precursor mrna , genetics , alternative splicing , biology , gene , rna

We have studied the splicing regulation of NF1 exons 36 and 37. We show that they not only require an intact exonic Splicing Enhancer (ESE) within exon 37, but also need the genomic region stretching from exons 31 to 38. Any nucleotide change in two exon 37 third codon positions disrupts the ESE. The extent of exons 36 and 37 skipping due to a mutated ESE depends on the genomic context. This is a unique example of what may be a more general phenomena involved in the tuning of pre‐mRNA processing and gene expression modulation in the chromosomal setting.

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