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The fission yeast Map4 protein is a novel adhesin required for mating
Author(s) -
Sharifmoghadam Mohammad Reza,
Bustos-Sanmamed Pilar,
Valdivieso Maria-Henar
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.07.016
Subject(s) - schizosaccharomyces pombe , bacterial adhesin , glycoprotein , yeast , cell adhesion , microbiology and biotechnology , biology , mating , serine , biochemistry , saccharomyces cerevisiae , virulence , cell , genetics , gene , phosphorylation
Cell adhesion is required for many cellular processes. In fungi, cell–cell contact during mating, flocculation or virulence is mediated by adhesins, which typically are glycosyl phosphatidyl inositol (GPI)‐modified cell wall glycoproteins. Proteins with internal repeats (PIR) are surface proteins involved in the response to stress. In Schizosaccharomyces pombe no adhesins or PIR proteins have been described. Here we study the S. pombe Map4p, which defines a new class of surface protein that is not GPI‐modified and has a serine/threonine rich domain and internal repeats that differ from those present in PIR proteins. Map4p is a mating type‐specific adhesin required for mating in h + cells and enhances cell adhesion when overexpressed.