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Cyprinid herpes virus‐3 (CyHV‐3) bears genes of genetically distant large DNA viruses
Author(s) -
Ilouze Maya,
Dishon Ar,
Kahan Tamar,
Kotler Moshe
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.07.013
Subject(s) - biology , virology , gene , virus , thymidine kinase , genome , dna virus , carp , genetics , herpes simplex virus , fishery , fish <actinopterygii>
A large DNA virus, designated koi herpes virus (KHV), carp interstitial nephritis gill necrosis virus (CNGV) and Cyprinid herpes virus‐3 (CyHV‐3), causes massive mortality of carp. Morphologically, the virus resembles herpes viruses, but it contains a genome of ca 295 kbp, larger than that of any Herpesviridae member. Interestingly, three CyHV‐3 genes, thymidylate monophosphate kinase (TmpK), ribonucleotide reductase and thymidine kinase, which are involved in deoxynucleotide tri‐phosphate synthesis, resemble those of pox viruses. In addition to the TmpK gene, which is nonexistent in the genome of herpes viruses, CyHV‐3 contains a B22R‐like gene, exclusively expressed by pox viruses. These results raise questions on the phylogenic origin of CyHV‐3.