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Some aspects of the venom proteome of the Colubridae snake Philodryas olfersii revealed from a Duvernoy's (venom) gland transcriptome
Author(s) -
Ching Ana T.C.,
Rocha Marisa M.T.,
Paes Leme Adriana F.,
Pimenta Daniel C.,
de Fátima D. Furtado Maria,
Serrano Solange M.T.,
Ho Paulo L.,
Junqueira-de-Azevedo Inácio L.M.
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.07.010
Subject(s) - viperidae , colubridae , venom , biology , elapidae , proteome , zoology , evolutionary biology , biochemistry
We investigated the putative toxins of Philodryas olfersii (Colubridae), a representative of a family of snakes neglected in venom studies despite their growing medical importance. Transcriptomic data of the venom gland complemented by proteomic analysis of the gland secretion revealed the presence of major toxin classes from the Viperidae family, including serine proteases, metalloproteases, C‐type lectins, Crisps, and a C‐type natriuretic peptide (CNP). Interestingly, the phylogenetic analysis of the CNP precursor showed it as a linker between two related precursors found in Viperidae and Elapidae snakes. We suggest that these precursors constitute a monophyletic group derived from the vertebrate CNPs.