Premium
Platelet derived growth factor regulates ABCA1 expression in vascular smooth muscle cells
Author(s) -
Nagao Sachi,
Murao Koji,
Imachi Hitomi,
Cao Wen-Ming,
Yu Xiao,
Li Junhua,
Matsumoto Kensuke,
Nishiuchi Takamasa,
Ahmed Rania A.M.,
Wong Norman C.W.,
Ueda Kazumitsu,
Ishida Toshihiko
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.07.001
Subject(s) - abca1 , platelet derived growth factor receptor , atp binding cassette transporter 1 , platelet derived growth factor , vascular smooth muscle , protein kinase b , microbiology and biotechnology , growth factor , phosphorylation , chemistry , biology , endocrinology , transporter , biochemistry , smooth muscle , receptor , gene
The ATP‐binding cassette transporter A1 (ABCA1) regulates lipid efflux from peripheral cells to High‐density lipoprotein. The platelet‐derived growth factor (PDGF) is a potent mitogen that enables vascular smooth muscle cells to participate in atherosclerosis. In this report, we showed that PDGF suppressed endogenous expression of ABCA1 in cultured vascular smooth muscle cells. Exposure of CRL‐208 cells to PDGF elicited a rapid phosphorylation of a kinase downstream from PI3‐K, Akt. The constitutively active form of both p110, a subunit of PI3‐K, and Akt inhibited activity of the ABCA1 promoter. In conclusion, PI3‐K‐Akt pathways participate in PDGF‐suppression of ABCA1 expression.