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Fractalkine and minocycline alter neuronal activity in the spinal cord dorsal horn
Author(s) -
Owolabi Samuel A.,
Saab Carl Y.
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.06.087
Subject(s) - minocycline , nociception , spinal cord , neuropathic pain , medicine , sciatic nerve , microglia , anesthesia , neuroscience , premovement neuronal activity , lumbar , central nervous system , chemistry , endocrinology , anatomy , inflammation , psychology , biochemistry , receptor , antibiotics
Fractalkine (FKN) evokes nociceptive behavior in naïve rats, whereas minocycline attenuates pain acutely after neuronal injury. We show that, in naïve rats, FKN causes hyperresponsiveness of lumbar wide dynamic range neurons to brush, pressure and pinch applied to the hindpaw. One day after spinal nerve ligation (SNL), minocycline attenuates after‐discharge and responses to brush and pressure. In contrast, minocycline does not alter evoked neuronal responses 10 days after SNL or sciatic constriction, but increases spontaneous discharge. We speculate that microglia rapidly alter sensory neuronal activity in naïve and neuropathic rats acutely, but not chronically, after injury.