Premium
Differential atrial versus ventricular ANKRD1 gene expression is oppositely regulated at diastolic heart failure
Author(s) -
Torrado Mario,
Nespereira Beatriz,
Bouzamayor Yolanda,
Centeno Alberto,
López Eduardo,
Mikhailov Alexander T.
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.06.073
Subject(s) - ventricle , heart failure , medicine , diastole , downregulation and upregulation , cardiology , endocrinology , chemistry , gene , biochemistry , blood pressure
Diastolic heart failure (DHF) was produced in 6‐day‐old piglets by intravenous administration of Doxorubicin, and ANKRD1 protein and mRNA levels were determined in atrial (A) and ventricular (V) chambers of failing vs control hearts. In controls, ANKRD1 showed a left–right (L–R) asymmetric distribution with protein levels 2‐fold higher in the LA as compared to the RA, and 8‐fold higher in the LV than the RV. In failing hearts, ANKRD1 levels were augmented about 2‐fold in each ventricle but equally reduced in both atria as compared to controls. ANKRD1 downregulation in atria is discussed as a process associated with advanced DHF.